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Orian, A., Gonen, H., Bercovich, B., Fajerman, I., Eytan, E., Israël, A., Mercurio, F., Iwai, K, Schwartz, A.L., and Ciechanover, A. (2000). SCFβ-TrCP Ubiquitin Ligase-Mediated Processing of NF-κB p105 Requires Phosphorylation of its C-Terminus by IκB Kinase. EMBO J. 19, 2580-2591. |
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Aviel, S., Winberg, G., Massucci, M., and Ciechanover, A. (2000). Degradation of Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway: Targeting via Ubiquitination of the N-Terminal Residue. J. Biol. Chem. 275, 23491-23499. |
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| Reinstein, E., Scheffner, M., Oren, M., Schwartz, A.L., and Ciechanover, A. (2000) Degradation of the E7 Human Papillomavirus Oncoprotein by the Ubiquitin-Proteasome System: Targeting via Ubiquitination of the N-Terminal Residue. Oncogene 19, 5944-5950. |
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Amir, R.E., Iwai, K., and Ciechanover, A. (2002). The NEDD8 pathway is required for for SCFβ-TrCP - mediated processing of the NF-κB precursor p105. J. Biol. Chem. 277, 23253-23259. |
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| Cohen, S., Orian, A., and Ciechanover, A. (2001). Processing of p105 is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition is Alleviated by Signaling via the C-Terminal Phosphorylation/Ubiquitin-Ligase Binding Domain. J. Biol. Chem. 276, 26769-26776. |
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| Ryoo, H.-D., Bergmann, A., Gonen, H., Ciechanover, A., and Steller, H. (2002). Regulation of Drosophila IAP1 Degradation and Apoptosis by Reaper and UbcD1. Nature Cell Biology 4, 432-438. |
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Ben-Izhak, O., Lahav-Baratz, S., Meretyk, S., Ben-Eliezer, S., Sabo, E., Dirnfeld, M., Cohen, S., and Ciechanover, A. (2003). Inverse Relationship Between Skp2 Ubiquitin Ligase and the Cyclin Dependent Kinase Inhibitor p27kip1 in Prostate Cancer. J. Urol. 170, 241-245. |
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Amir, R.E., Haecker, H., Karin, M., and Ciechanover, A. (2004) Mechanism of Processing of the NF-κB2 p100 Precursor: Identification of the Specific Polyubiquitin Chain-Anchoring Lysine Residue and Analysis of the Role of NEDD8-Modification on the SCFβ-TrCP Ubiquitin Ligase. Oncogene 23, 2540-2547. |
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Cohen, S., Achbert-Weiner, H., and Ciechanover, A. (2004). Dual Effect of IKKβ-Mediated Phosphorylation on p105 Fate: SCFβ-TrCP- Dependent Degradation and SCFβ-TrCP- Independent Processing. Mol. Cell. Biol. 24, 475-486. |
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| Fajerman, I., Schawartz, A.L., and Ciechanover, A. Degradation of the Id2 Developmental regulator: Targeting via N-Terminal Ubiquitination. Biochem. Biophys. Res. Commun. 314, 505-512. |
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Ben-Saadon, R., Fajerman, I., Ziv, T., Hellman, U., Schwartz, A.L., and Ciechanover, A. (2004). The Tumor Suppressor Protein p16INK4a and the Human Papillomavirus oncoprotein E7-58 are Naturally Occurring Lysine-Less Proteins that are Degraded by the Ubiquitin System: Direct Evidence for Ubiquitination at the N-Terminal Residue. J. Biol. Chem. 279, 41414-41421. |
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Cohen, S., Lahav-Baratz, S., and Ciechanover, A. (2006). Two Distinct Ubiquitin-Dependent Mechanisms are involved in NF-κB p105 Proteolysis. Biochem. Biophys. Res. Commn. 345, 7-13. |
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| Herman- Bachinsky, Y., Ryoo, H.D., Ciechanover, A.*, and Gonen, H. (2007). Regulation of the Drosophila Ubiquitin Ligase DIAP1 is Mediated via Several Distinct Ubiquitin System Pathways. Cell Death and Differentiation. 14, 861-871. *Senior correspoinding author. |
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| Ben Saadon, R., Zaarur, D., Ziv, T., and Ciechanover, A. (2006). The Polycomb Protein Ring1B Generates Self Atypical Mixed Ubiquitin Chains Required for its In Vitro Histone H2A Ligase Activity. Mol. Cell. 24, 701-711. |
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Sadeh, R., Breitschopf, K., Bercovich, B., Zoabi, M., Kravtsova-Ivantsiv, Y., Kornitzer, D., Schwartz, A.L., and Ciechanover, A. (2008). The N-Terminal Domain of MyoD is Necessary and Sufficient for its Nuclear Localization-Dependent Degradation by the Ubiquitin System. Proc. Natl. Acad. Sci. USA 105, 15690-15695 |
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| Shabek, N., Iwai, K., and Ciechanover, A. (2007). Ubiquitin is Degraded by the Ubiquitin System as a Monomer and as Part of its Conjugated Target. Biochem. Biophys. Res. Commun. 363, 425-31. |
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Kravtsova-Ivantsiv, Y., Cohen, S., and Ciechanover, A. (2009). Modification by Single Ubiquitin Moieties Rather Than Polyubiquitination is Sufficient for Proteasomal Processing of the p105 NF-κB Precursor. Mol. Cell. 33, 496-504. |
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Shabek, N., Herman-Bachinsky, Y., and Ciechanover, A. (2009). Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. Proc. Natl. Acad. Sci. USA 106, 11907-11912. |
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Shabek, N., Ciechanover, A. (2010). Degradation of ubiquitin: the fate of the cellular reaper. Cell Cycle 9, 523-530. |
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Zaaroor-Regev, D., de-bie, P., Scheffner, M., Noy, T., Shemer, R., Heled, M., Stein, I., Pikarsky, E., and Ciechanover, A. (2010). Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proc. Natl. Acad. Sci. USA 107, 1-6. |
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